Sustainable Green Synthesis of Zinc Oxide Nanoparticles with Clove and Cinnamon: A Study on Antioxidant and Cytotoxic Properties

Authors

  • Sangeetha V SRIHER (DU), Porur, Chennai
  • Hemalatha S Department of Pharmacognosy, Sri Ramachandra Faculty of Pharmacy, SRIHER (DU), Porur, Chennai
  • Hemamalini A. J Department of Clinical Nutrition, Sri Ramachandra Faculty of Allied Health Sciences, SRIHER (DU), Porur, Chennai

DOI:

https://doi.org/10.5530/ctbp.2025.4s.27

Keywords:

ZnO NP, Green synthesis, Antioxidant activity, Cytotoxicity assay

Abstract

This study explores the green synthesis of zinc oxide nanoparticles (ZnO NPs) using clove and cinnamon extracts as natural reducing agents. The eco-friendly approach minimizes toxic chemicals, making it a sustainable alternative to conventional methods. The synthesized ZnO NPs were characterized using UV, SEM, FTIR, XRD, and DLS techniques. Antioxidant activity was assessed via DPPH and nitric oxide scavenging assays, revealing significant radical scavenging properties. Cytotoxicity analysis against HepG2 cells demonstrated dose-dependent effects, with an IC50 value of 147.44 μg/mL, suggesting potential anticancer applications. These findings highlight the dual benefits of green synthesis—environmental sustainability and biomedical potential—positioning ZnO NPs as promising agents in pharmaceuticals, cosmetics, and environmental applications.

DPPH Radical Scavenging Assay of green synthesized ZnO nanoparticles

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Published

30-10-2025

How to Cite

V, S. ., S, H. ., & J, H. A. (2025). Sustainable Green Synthesis of Zinc Oxide Nanoparticles with Clove and Cinnamon: A Study on Antioxidant and Cytotoxic Properties. Current Trends in Biotechnology and Pharmacy, 19(4s), 257–262. https://doi.org/10.5530/ctbp.2025.4s.27

Issue

Vol. 19 No. 4s (2025): Current Trends in Biotechnology and Pharmacy

Section

Research Paper