In-Silico Molecular Docking Studies of Crinum Solapurense: For Cox-Inhibition

Authors

  • Anup A. Dhange D.S.T.S. Mandal’s College of Pharmacy, Solapur, (Maharashtra)
  • Ganesh B. Gajeli D.S.T.S. Mandal’s College of Pharmacy, Solapur, (Maharashtra)
  • Shrishail M. Ghurghure Department of Pharmaceutics, School of Pharmacy, MIT Vishwaprayag University, Solapur
  • Shreyash M. Moharir Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Pune, (Maharashtra)
  • Dr. Chandrashkar D Bobade School of Health Science and Technology, Dr.Vishwanathkarad MIT World Peace University, Pune

DOI:

https://doi.org/10.5530/ctbp.2026.3.24

Keywords:

Crinum Solapurense, Amaryllidaceae, AutoDock Vina, Lycorine, cyclooxygenase- 2 etc

Abstract

In the present study, an aim was to identify adrug-likecandidate for the plant Crinum Solapurense( Amaryllidaceae).The Lycorine, an alkaloid that could be a potential candidate which can interact and inhibits the cyclooxygenase-2 (COX-2) generated protein 5KIR and relieves pain and inflammation.Total 18 compounds were analyzed through, Autodock vina. The docking value was observed in the range of -9.4 to −10.3 kcal·mol⁻¹. No other article and review have been reported for the molecular docking study for the plant Crinum Solapurense.Moreover, there have been some articles of plants belonging to the family Amaryllidaceae.

Crinum Solapurense Plant

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Published

21-07-2026

How to Cite

Dhange, A. A. ., Gajeli, G. B. ., Ghurghure, S. M. ., Moharir, S. M. ., & Bobade, D. C. D. . (2026). In-Silico Molecular Docking Studies of Crinum Solapurense: For Cox-Inhibition. Current Trends in Biotechnology and Pharmacy, 20(3), 3008–3020. https://doi.org/10.5530/ctbp.2026.3.24

Issue

Vol. 20 No. 3 (2026): Current Trends in Biotechnology and Pharmacy

Section

Research Paper