Evaluation of Central Nervous System Activities of Dhanwantaram Kashayam in Experimental Animal Models

Abstract

Ayurveda is a traditional Indian medic- inal system that has been practiced for centu- ries and is known as the “Mother of All Healing.” According to the World Health Organization, 80% of the world’s population still relies primar- ily on traditional medicines for their healthcare. The purpose of the study was to evaluate and confirm the CNS activities of Dhanwantaram Kashayam, an ayurvedic formulation, in ex- perimental animal models. It is a decoction of many herbs that is commonly used for labour pain relief and is given at random for sever- al vata disorders. Because there is not much available literature on it, the following study is to confirm the hypothesis.The animal models selected were tests for anti-convulsant activi- ty, anti-anxiety activity, anti-depressant activity, and muscle coordination activity. The study en- tails that Dhanwantaram Kashayam polyhedral formulation has highly significant (P<0.001) ant anxiety, antidepressant, analgesic, and muscle relaxant properties. In addition to that, it also has a sedative effect. It was concluded that the Dhanwantaram Kashayam at a high dose (0.5 ml/kg) shows anticonvulsant, antidepressant, anti-anxiety, analgesic, and muscle relaxant ac- tivity, whereas the low dose (0.25 ml/kg) shows a sedative effect.